Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2356938..2357460 Replicon chromosome
Accession NZ_CP100732
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL737_RS11340 Protein ID WP_000221343.1
Coordinates 2357176..2357460 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL737_RS11335 Protein ID WP_000885424.1
Coordinates 2356938..2357186 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL737_RS11310 (2352154) 2352154..2353620 + 1467 WP_000987828.1 hypothetical protein -
NL737_RS11315 (2354428) 2354428..2355142 + 715 Protein_2212 helix-turn-helix domain-containing protein -
NL737_RS11320 (2355198) 2355198..2356106 - 909 WP_010989018.1 hypothetical protein -
NL737_RS11325 (2356249) 2356249..2356581 - 333 WP_000253154.1 DUF1493 family protein -
NL737_RS11330 (2356571) 2356571..2356786 - 216 WP_000206207.1 hypothetical protein -
NL737_RS11335 (2356938) 2356938..2357186 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL737_RS11340 (2357176) 2357176..2357460 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL737_RS11345 (2357631) 2357631..2358020 + 390 WP_000194089.1 RidA family protein -
NL737_RS11350 (2358072) 2358072..2359151 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL737_RS11355 (2359344) 2359344..2359832 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL737_RS11360 (2359877) 2359877..2361385 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2352157..2364242 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251267 WP_000221343.1 NZ_CP100732:2357176-2357460 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251267 WP_000885424.1 NZ_CP100732:2356938-2357186 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References