Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 364799..365337 Replicon chromosome
Accession NZ_CP100732
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag NL737_RS01660 Protein ID WP_001526148.1
Coordinates 365062..365337 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag NL737_RS01655 Protein ID WP_000729713.1
Coordinates 364799..365059 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL737_RS01635 (360352) 360352..361905 + 1554 WP_000013007.1 TROVE domain-containing protein -
NL737_RS01640 (361914) 361914..362105 + 192 Protein_324 TROVE domain-containing protein -
NL737_RS01645 (362453) 362453..363667 + 1215 WP_001105521.1 RNA-splicing ligase RtcB -
NL737_RS01650 (363671) 363671..364690 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
NL737_RS01655 (364799) 364799..365059 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL737_RS01660 (365062) 365062..365337 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
NL737_RS01665 (365425) 365425..368130 - 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T251259 WP_001526148.1 NZ_CP100732:365062-365337 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT251259 WP_000729713.1 NZ_CP100732:364799-365059 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References