251253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4731588..4732190 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL731_RS23170 Protein ID WP_001159635.1
Coordinates 4731879..4732190 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL731_RS23165 Protein ID WP_000362050.1
Coordinates 4731588..4731878 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS23150 (4729081) 4729081..4729983 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NL731_RS23155 (4729980) 4729980..4730615 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL731_RS23160 (4730612) 4730612..4731541 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL731_RS23165 (4731588) 4731588..4731878 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL731_RS23170 (4731879) 4731879..4732190 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL731_RS23175 (4732408) 4732408..4733337 + 930 WP_001127705.1 alpha/beta hydrolase -
NL731_RS23180 (4733423) 4733423..4733734 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
NL731_RS23185 (4733731) 4733731..4734177 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL731_RS23190 (4734192) 4734192..4735133 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL731_RS23195 (4735178) 4735178..4735615 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
NL731_RS23200 (4735612) 4735612..4736484 - 873 WP_000921423.1 virulence factor BrkB family protein -
NL731_RS23205 (4736478) 4736478..4737077 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251253 WP_001159635.1 NZ_CP100728:c4732190-4731879 [Salmonella enterica subsp. enterica serovar Blockley]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251253 WP_000362050.1 NZ_CP100728:c4731878-4731588 [Salmonella enterica subsp. enterica serovar Blockley]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97


Antitoxin

Source ID Structure

References