251234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4560687..4561289 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL714_RS22325 Protein ID WP_001159635.1
Coordinates 4560978..4561289 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL714_RS22320 Protein ID WP_000362050.1
Coordinates 4560687..4560977 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS22305 (4558180) 4558180..4559082 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NL714_RS22310 (4559079) 4559079..4559714 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL714_RS22315 (4559711) 4559711..4560640 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
NL714_RS22320 (4560687) 4560687..4560977 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL714_RS22325 (4560978) 4560978..4561289 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL714_RS22330 (4561507) 4561507..4562436 + 930 WP_001127705.1 alpha/beta hydrolase -
NL714_RS22335 (4562522) 4562522..4562833 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
NL714_RS22340 (4562830) 4562830..4563276 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NL714_RS22345 (4563291) 4563291..4564232 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL714_RS22350 (4564277) 4564277..4564714 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
NL714_RS22355 (4564711) 4564711..4565583 - 873 WP_000921423.1 virulence factor BrkB family protein -
NL714_RS22360 (4565577) 4565577..4566176 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251234 WP_001159635.1 NZ_CP100724:c4561289-4560978 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251234 WP_000362050.1 NZ_CP100724:c4560977-4560687 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97


Antitoxin

Source ID Structure

References