251183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2424847..2425369 Replicon chromosome
Accession NZ_CP100715
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.5474

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL730_RS11945 Protein ID WP_000221343.1
Coordinates 2425085..2425369 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL730_RS11940 Protein ID WP_000885424.1
Coordinates 2424847..2425095 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL730_RS11915 (2420063) 2420063..2421529 + 1467 WP_000987828.1 hypothetical protein -
NL730_RS11920 (2422337) 2422337..2423051 + 715 Protein_2332 helix-turn-helix domain-containing protein -
NL730_RS11925 (2423107) 2423107..2424015 - 909 WP_010989018.1 hypothetical protein -
NL730_RS11930 (2424158) 2424158..2424490 - 333 WP_000253154.1 DUF1493 family protein -
NL730_RS11935 (2424480) 2424480..2424695 - 216 WP_000206207.1 hypothetical protein -
NL730_RS11940 (2424847) 2424847..2425095 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL730_RS11945 (2425085) 2425085..2425369 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL730_RS11950 (2425540) 2425540..2425929 + 390 WP_000194089.1 RidA family protein -
NL730_RS11955 (2425981) 2425981..2427060 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL730_RS11960 (2427253) 2427253..2427741 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL730_RS11965 (2427786) 2427786..2429294 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2420066..2432151 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251183 WP_000221343.1 NZ_CP100715:2425085-2425369 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251183 WP_000885424.1 NZ_CP100715:2424847-2425095 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References