251172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 21049..21760 Replicon plasmid pR18.0186_78k
Accession NZ_CP100711
Organism Salmonella enterica subsp. enterica serovar Blockley strain R18.0186

Toxin (Protein)


Gene name higB Uniprot ID I2UJZ0
Locus tag NL733_RS24060 Protein ID WP_000162415.1
Coordinates 21458..21760 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL733_RS24055 Protein ID WP_000806445.1
Coordinates 21049..21387 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL733_RS24025 (NL733_24025) 16332..17165 - 834 WP_226149389.1 hypothetical protein -
NL733_RS24030 (NL733_24030) 17511..18164 + 654 WP_086776826.1 maturation control protein -
NL733_RS24035 (NL733_24035) 18493..18822 + 330 WP_000542383.1 hypothetical protein -
NL733_RS24040 (NL733_24040) 18815..20008 + 1194 WP_063074560.1 hypothetical protein -
NL733_RS24045 (NL733_24045) 20042..20770 - 729 WP_063074812.1 hypothetical protein -
NL733_RS24050 (NL733_24050) 20807..20992 - 186 Protein_37 hypothetical protein -
NL733_RS24055 (NL733_24055) 21049..21387 - 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
NL733_RS24060 (NL733_24060) 21458..21760 - 303 WP_000162415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL733_RS24065 (NL733_24065) 21923..22714 + 792 WP_063074813.1 hypothetical protein -
NL733_RS24070 (NL733_24070) 22711..23478 + 768 WP_000203293.1 hypothetical protein -
NL733_RS24075 (NL733_24075) 23482..24462 + 981 WP_047647145.1 hypothetical protein -
NL733_RS24080 (NL733_24080) 24459..25112 + 654 WP_032342060.1 hypothetical protein -
NL733_RS24085 (NL733_24085) 25172..26077 + 906 WP_032342061.1 recombination-associated protein RdgC -
NL733_RS24090 (NL733_24090) 26121..26741 + 621 WP_044862276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR - 1..77896 77896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11818.56 Da        Isoelectric Point: 9.8739

>T251172 WP_000162415.1 NZ_CP100711:c21760-21458 [Salmonella enterica subsp. enterica serovar Blockley]
MTKKINIKDFRDAWLDDFFEFSTPHRKIPPDIHMTLSRKLDIINAATTCKDLRSPPGNRYEELSGKLNGYSSVRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT251172 WP_000806445.1 NZ_CP100711:c21387-21049 [Salmonella enterica subsp. enterica serovar Blockley]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A631VBQ3

Antitoxin

Source ID Structure

References