251169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4698999..4699601 Replicon chromosome
Accession NZ_CP100710
Organism Salmonella enterica subsp. enterica serovar Blockley strain R18.0186

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL733_RS22925 Protein ID WP_001159635.1
Coordinates 4699290..4699601 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL733_RS22920 Protein ID WP_000362050.1
Coordinates 4698999..4699289 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL733_RS22905 (4696492) 4696492..4697394 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NL733_RS22910 (4697391) 4697391..4698026 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL733_RS22915 (4698023) 4698023..4698952 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL733_RS22920 (4698999) 4698999..4699289 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL733_RS22925 (4699290) 4699290..4699601 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL733_RS22930 (4699819) 4699819..4700748 + 930 WP_001127705.1 alpha/beta hydrolase -
NL733_RS22935 (4700834) 4700834..4701145 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
NL733_RS22940 (4701142) 4701142..4701588 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL733_RS22945 (4701603) 4701603..4702544 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL733_RS22950 (4702589) 4702589..4703026 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
NL733_RS22955 (4703023) 4703023..4703895 - 873 WP_000921423.1 virulence factor BrkB family protein -
NL733_RS22960 (4703889) 4703889..4704488 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251169 WP_001159635.1 NZ_CP100710:c4699601-4699290 [Salmonella enterica subsp. enterica serovar Blockley]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251169 WP_000362050.1 NZ_CP100710:c4699289-4698999 [Salmonella enterica subsp. enterica serovar Blockley]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References