251138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2433404..2433926 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL735_RS12005 Protein ID WP_000221343.1
Coordinates 2433642..2433926 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL735_RS12000 Protein ID WP_000885424.1
Coordinates 2433404..2433652 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS11975 (2428620) 2428620..2430086 + 1467 WP_000987828.1 hypothetical protein -
NL735_RS11980 (2430894) 2430894..2431608 + 715 Protein_2344 helix-turn-helix domain-containing protein -
NL735_RS11985 (2431664) 2431664..2432572 - 909 WP_010989018.1 hypothetical protein -
NL735_RS11990 (2432715) 2432715..2433047 - 333 WP_000253154.1 DUF1493 family protein -
NL735_RS11995 (2433037) 2433037..2433252 - 216 WP_000206207.1 hypothetical protein -
NL735_RS12000 (2433404) 2433404..2433652 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL735_RS12005 (2433642) 2433642..2433926 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL735_RS12010 (2434097) 2434097..2434486 + 390 WP_000194089.1 RidA family protein -
NL735_RS12015 (2434538) 2434538..2435617 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL735_RS12020 (2435810) 2435810..2436298 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL735_RS12025 (2436343) 2436343..2437851 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2428623..2440708 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251138 WP_000221343.1 NZ_CP100707:2433642-2433926 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251138 WP_000885424.1 NZ_CP100707:2433404-2433652 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References