Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4571466..4572068 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL734_RS22330 Protein ID WP_001159635.1
Coordinates 4571757..4572068 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL734_RS22325 Protein ID WP_000362050.1
Coordinates 4571466..4571756 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS22310 (4568959) 4568959..4569861 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NL734_RS22315 (4569858) 4569858..4570493 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
NL734_RS22320 (4570490) 4570490..4571419 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL734_RS22325 (4571466) 4571466..4571756 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL734_RS22330 (4571757) 4571757..4572068 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL734_RS22335 (4572286) 4572286..4573215 + 930 WP_001127708.1 alpha/beta hydrolase -
NL734_RS22340 (4573301) 4573301..4573612 + 312 WP_017465947.1 type II toxin-antitoxin system HigB family toxin -
NL734_RS22345 (4573609) 4573609..4574055 + 447 WP_017465948.1 type II toxin-antitoxin system HigA family antitoxin -
NL734_RS22350 (4574070) 4574070..4575011 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL734_RS22355 (4575056) 4575056..4575493 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NL734_RS22360 (4575490) 4575490..4576362 - 873 WP_000921423.1 virulence factor BrkB family protein -
NL734_RS22365 (4576356) 4576356..4576955 - 600 WP_001621364.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251120 WP_001159635.1 NZ_CP100702:c4572068-4571757 [Salmonella enterica subsp. enterica serovar Thompson]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251120 WP_000362050.1 NZ_CP100702:c4571756-4571466 [Salmonella enterica subsp. enterica serovar Thompson]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References