Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4529982..4530584 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL712_RS21855 Protein ID WP_001159635.1
Coordinates 4530273..4530584 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL712_RS21850 Protein ID WP_000362050.1
Coordinates 4529982..4530272 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS21835 (4527475) 4527475..4528377 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NL712_RS21840 (4528374) 4528374..4529009 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL712_RS21845 (4529006) 4529006..4529935 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL712_RS21850 (4529982) 4529982..4530272 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL712_RS21855 (4530273) 4530273..4530584 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL712_RS21860 (4530802) 4530802..4531731 + 930 WP_023255277.1 alpha/beta hydrolase -
NL712_RS21865 (4531817) 4531817..4532128 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
NL712_RS21870 (4532125) 4532125..4532571 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL712_RS21875 (4532586) 4532586..4533527 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL712_RS21880 (4533572) 4533572..4534009 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
NL712_RS21885 (4534006) 4534006..4534878 - 873 WP_023255278.1 virulence factor BrkB family protein -
NL712_RS21890 (4534872) 4534872..4535471 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251064 WP_001159635.1 NZ_CP100693:c4530584-4530273 [Salmonella enterica subsp. enterica serovar London]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251064 WP_000362050.1 NZ_CP100693:c4530272-4529982 [Salmonella enterica subsp. enterica serovar London]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References