251057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2329179..2329701 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL712_RS11225 Protein ID WP_000221343.1
Coordinates 2329417..2329701 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL712_RS11220 Protein ID WP_000885424.1
Coordinates 2329179..2329427 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS11195 (2325272) 2325272..2326738 + 1467 WP_077946914.1 hypothetical protein -
NL712_RS11200 (2327040) 2327040..2327330 + 291 WP_000742001.1 hypothetical protein -
NL712_RS11205 (2327683) 2327683..2328409 + 727 Protein_2189 helix-turn-helix domain-containing protein -
NL712_RS11210 (2328490) 2328490..2328822 - 333 WP_000253154.1 DUF1493 family protein -
NL712_RS11215 (2328812) 2328812..2329027 - 216 WP_000206207.1 hypothetical protein -
NL712_RS11220 (2329179) 2329179..2329427 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL712_RS11225 (2329417) 2329417..2329701 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL712_RS11230 (2329872) 2329872..2330261 + 390 WP_000194089.1 RidA family protein -
NL712_RS11235 (2330313) 2330313..2331392 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL712_RS11240 (2331585) 2331585..2332073 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL712_RS11245 (2332118) 2332118..2333626 + 1509 WP_058214747.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2325275..2336483 11208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251057 WP_000221343.1 NZ_CP100693:2329417-2329701 [Salmonella enterica subsp. enterica serovar London]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251057 WP_000885424.1 NZ_CP100693:2329179-2329427 [Salmonella enterica subsp. enterica serovar London]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References