251047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4779952..4780554 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NL690_RS23350 Protein ID WP_001159630.1
Coordinates 4780243..4780554 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL690_RS23345 Protein ID WP_000362050.1
Coordinates 4779952..4780242 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS23330 (4777445) 4777445..4778347 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NL690_RS23335 (4778344) 4778344..4778979 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL690_RS23340 (4778976) 4778976..4779905 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL690_RS23345 (4779952) 4779952..4780242 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL690_RS23350 (4780243) 4780243..4780554 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL690_RS23355 (4780772) 4780772..4781701 + 930 WP_001127703.1 alpha/beta hydrolase -
NL690_RS23360 (4781787) 4781787..4782098 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NL690_RS23365 (4782095) 4782095..4782541 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL690_RS23370 (4782556) 4782556..4783497 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL690_RS23375 (4783542) 4783542..4783979 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NL690_RS23380 (4783976) 4783976..4784848 - 873 WP_000921427.1 virulence factor BrkB family protein -
NL690_RS23385 (4784842) 4784842..4785441 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251047 WP_001159630.1 NZ_CP100691:c4780554-4780243 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251047 WP_000362050.1 NZ_CP100691:c4780242-4779952 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References