251043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2544737..2545259 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL690_RS12445 Protein ID WP_000221343.1
Coordinates 2544975..2545259 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL690_RS12440 Protein ID WP_000885424.1
Coordinates 2544737..2544985 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS12415 (2539953) 2539953..2541419 + 1467 WP_000987828.1 hypothetical protein -
NL690_RS12420 (2542227) 2542227..2542941 + 715 Protein_2431 helix-turn-helix domain-containing protein -
NL690_RS12425 (2542997) 2542997..2543905 - 909 WP_010989018.1 hypothetical protein -
NL690_RS12430 (2544048) 2544048..2544380 - 333 WP_000253154.1 DUF1493 family protein -
NL690_RS12435 (2544370) 2544370..2544585 - 216 WP_000206207.1 hypothetical protein -
NL690_RS12440 (2544737) 2544737..2544985 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL690_RS12445 (2544975) 2544975..2545259 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL690_RS12450 (2545430) 2545430..2545819 + 390 WP_000194089.1 RidA family protein -
NL690_RS12455 (2545871) 2545871..2546950 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL690_RS12460 (2547143) 2547143..2547631 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL690_RS12465 (2547676) 2547676..2549184 + 1509 WP_099949671.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2541701..2552041 10340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251043 WP_000221343.1 NZ_CP100691:2544975-2545259 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251043 WP_000885424.1 NZ_CP100691:2544737-2544985 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References