Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4557433..4558035 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag FGU70_RS21995 Protein ID WP_001159632.1
Coordinates 4557724..4558035 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGU70_RS21990 Protein ID WP_000362050.1
Coordinates 4557433..4557723 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS21975 (4554926) 4554926..4555828 + 903 WP_000331365.1 formate dehydrogenase subunit beta -
FGU70_RS21980 (4555825) 4555825..4556460 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
FGU70_RS21985 (4556457) 4556457..4557386 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
FGU70_RS21990 (4557433) 4557433..4557723 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
FGU70_RS21995 (4557724) 4557724..4558035 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
FGU70_RS22000 (4558253) 4558253..4559182 + 930 WP_001127702.1 alpha/beta hydrolase -
FGU70_RS22005 (4559268) 4559268..4559579 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
FGU70_RS22010 (4559576) 4559576..4560022 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
FGU70_RS22015 (4560037) 4560037..4560978 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
FGU70_RS22020 (4561023) 4561023..4561460 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
FGU70_RS22025 (4561457) 4561457..4562329 - 873 WP_000921423.1 virulence factor BrkB family protein -
FGU70_RS22030 (4562323) 4562323..4562922 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T251031 WP_001159632.1 NZ_CP100689:c4558035-4557724 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251031 WP_000362050.1 NZ_CP100689:c4557723-4557433 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References