Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4450793..4451395 Replicon chromosome
Accession NZ_CP100685
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.1297

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag FC640_RS21235 Protein ID WP_001159630.1
Coordinates 4451084..4451395 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FC640_RS21230 Protein ID WP_000362050.1
Coordinates 4450793..4451083 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC640_RS21215 (4448286) 4448286..4449188 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
FC640_RS21220 (4449185) 4449185..4449820 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
FC640_RS21225 (4449817) 4449817..4450746 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
FC640_RS21230 (4450793) 4450793..4451083 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
FC640_RS21235 (4451084) 4451084..4451395 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
FC640_RS21240 (4451613) 4451613..4452542 + 930 WP_001127694.1 alpha/beta hydrolase -
FC640_RS21245 (4452628) 4452628..4452939 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin -
FC640_RS21250 (4452936) 4452936..4453382 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
FC640_RS21255 (4453397) 4453397..4454338 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
FC640_RS21260 (4454383) 4454383..4454820 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
FC640_RS21265 (4454817) 4454817..4455689 - 873 WP_000921423.1 virulence factor BrkB family protein -
FC640_RS21270 (4455683) 4455683..4456282 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251014 WP_001159630.1 NZ_CP100685:c4451395-4451084 [Salmonella enterica subsp. enterica serovar Goldcoast]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251014 WP_000362050.1 NZ_CP100685:c4451083-4450793 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References