Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4720866..4721468 Replicon chromosome
Accession NZ_CP100670
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag NL713_RS22860 Protein ID WP_001159628.1
Coordinates 4720866..4721177 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL713_RS22865 Protein ID WP_000362050.1
Coordinates 4721178..4721468 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL713_RS22825 (4715979) 4715979..4716578 + 600 WP_000965702.1 glucose-1-phosphatase -
NL713_RS22830 (4716572) 4716572..4717444 + 873 WP_254520477.1 virulence factor BrkB family protein -
NL713_RS22835 (4717441) 4717441..4717878 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NL713_RS22840 (4717923) 4717923..4718864 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL713_RS22845 (4718879) 4718879..4719325 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL713_RS22850 (4719322) 4719322..4719633 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NL713_RS22855 (4719719) 4719719..4720648 - 930 WP_017441897.1 alpha/beta hydrolase -
NL713_RS22860 (4720866) 4720866..4721177 + 312 WP_001159628.1 hypothetical protein Toxin
NL713_RS22865 (4721178) 4721178..4721468 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL713_RS22870 (4721515) 4721515..4722444 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL713_RS22875 (4722441) 4722441..4723076 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL713_RS22880 (4723073) 4723073..4723975 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T250963 WP_001159628.1 NZ_CP100670:4720866-4721177 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT250963 WP_000362050.1 NZ_CP100670:4721178-4721468 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References