Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4744617..4745219 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NL709_RS23230 Protein ID WP_001159635.1
Coordinates 4744617..4744928 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL709_RS23235 Protein ID WP_000362050.1
Coordinates 4744929..4745219 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS23195 (4739730) 4739730..4740329 + 600 WP_000965695.1 glucose-1-phosphatase -
NL709_RS23200 (4740323) 4740323..4741195 + 873 WP_000921423.1 virulence factor BrkB family protein -
NL709_RS23205 (4741192) 4741192..4741629 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
NL709_RS23210 (4741674) 4741674..4742615 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL709_RS23215 (4742630) 4742630..4743076 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NL709_RS23220 (4743073) 4743073..4743384 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
NL709_RS23225 (4743470) 4743470..4744399 - 930 WP_001127705.1 alpha/beta hydrolase -
NL709_RS23230 (4744617) 4744617..4744928 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL709_RS23235 (4744929) 4744929..4745219 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL709_RS23240 (4745266) 4745266..4746195 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
NL709_RS23245 (4746192) 4746192..4746827 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL709_RS23250 (4746824) 4746824..4747726 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T250940 WP_001159635.1 NZ_CP100666:4744617-4744928 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT250940 WP_000362050.1 NZ_CP100666:4744929-4745219 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References