250918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4841838..4842442 Replicon chromosome
Accession NZ_CP100660
Organism Pseudomonas fluorescens strain ZL22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLL86_RS22245 Protein ID WP_254481237.1
Coordinates 4841838..4842158 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLL86_RS22250 Protein ID WP_254481238.1
Coordinates 4842155..4842442 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLL86_RS22220 (NLL86_22220) 4837402..4837632 + 231 WP_254481233.1 cysteine-rich CWC family protein -
NLL86_RS22225 (NLL86_22225) 4837676..4838377 + 702 WP_254481234.1 pseudouridine synthase -
NLL86_RS22230 (NLL86_22230) 4838701..4839600 + 900 WP_254481235.1 alpha/beta hydrolase -
NLL86_RS22240 (NLL86_22240) 4839985..4841685 + 1701 WP_254481236.1 SulP family inorganic anion transporter -
NLL86_RS22245 (NLL86_22245) 4841838..4842158 + 321 WP_254481237.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLL86_RS22250 (NLL86_22250) 4842155..4842442 + 288 WP_254481238.1 NadS family protein Antitoxin
NLL86_RS22255 (NLL86_22255) 4842589..4843599 + 1011 WP_254481239.1 DUF4917 family protein -
NLL86_RS22260 (NLL86_22260) 4843616..4844830 - 1215 WP_254481240.1 SAM-dependent methyltransferase -
NLL86_RS22265 (NLL86_22265) 4844904..4845521 - 618 WP_254481241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12028.97 Da        Isoelectric Point: 10.2237

>T250918 WP_254481237.1 NZ_CP100660:4841838-4842158 [Pseudomonas fluorescens]
MLFIETPIFTKRVKELLEDGIYRLLQVKLMSAPDAGDLIEGTGGLRKLRVAASGHGKRGGARVIYYHFTSSSQIAMLYIF
PKNEQSDLSAEQRKALKNIIEHWRHT

Download         Length: 321 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10880.47 Da        Isoelectric Point: 8.8726

>AT250918 WP_254481238.1 NZ_CP100660:4842155-4842442 [Pseudomonas fluorescens]
VSKFFEELMESVQQMDEIVQGKRVPSREVEIDALQVRSIRKSTGLSQVRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIRNDPDHVLRALAH

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References