Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5410175..5410770 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NLS69_RS25335 Protein ID WP_003113526.1
Coordinates 5410492..5410770 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLS69_RS25330 Protein ID WP_003099268.1
Coordinates 5410175..5410480 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS25295 (NLS69_25295) 5405314..5406162 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
NLS69_RS25305 (NLS69_25305) 5406329..5407270 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
NLS69_RS25310 (NLS69_25310) 5407387..5408001 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
NLS69_RS25315 (NLS69_25315) 5408043..5408627 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
NLS69_RS25320 (NLS69_25320) 5408668..5409768 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
NLS69_RS25330 (NLS69_25330) 5410175..5410480 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
NLS69_RS25335 (NLS69_25335) 5410492..5410770 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLS69_RS25340 (NLS69_25340) 5410823..5410951 - 129 Protein_5005 integrase -
NLS69_RS25345 (NLS69_25345) 5411099..5413327 + 2229 WP_025271371.1 TonB-dependent receptor -
NLS69_RS25350 (NLS69_25350) 5413397..5414044 - 648 WP_003095021.1 carbonate dehydratase -
NLS69_RS25355 (NLS69_25355) 5414106..5415344 - 1239 WP_025271372.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T250913 WP_003113526.1 NZ_CP100653:c5410770-5410492 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT250913 WP_003099268.1 NZ_CP100653:c5410480-5410175 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References