Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4784483..4785164 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLS69_RS22455 Protein ID WP_015503432.1
Coordinates 4784799..4785164 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLS69_RS22450 Protein ID WP_016561576.1
Coordinates 4784483..4784806 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS22415 (NLS69_22415) 4780375..4781058 - 684 WP_003120766.1 TetR/AcrR family transcriptional regulator -
NLS69_RS22420 (NLS69_22420) 4781146..4782024 + 879 WP_003163191.1 hypothetical protein -
NLS69_RS22430 (NLS69_22430) 4782627..4782854 + 228 WP_014603215.1 hypothetical protein -
NLS69_RS22435 (NLS69_22435) 4782869..4783861 - 993 Protein_4438 tyrosine-type recombinase/integrase -
NLS69_RS22440 (NLS69_22440) 4783861..4784253 - 393 Protein_4439 hypothetical protein -
NLS69_RS22445 (NLS69_22445) 4784248..4784367 + 120 Protein_4440 IS5/IS1182 family transposase -
NLS69_RS22450 (NLS69_22450) 4784483..4784806 - 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
NLS69_RS22455 (NLS69_22455) 4784799..4785164 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLS69_RS22460 (NLS69_22460) 4785428..4785670 - 243 WP_043884955.1 hypothetical protein -
NLS69_RS22465 (NLS69_22465) 4785877..4786149 + 273 WP_003085667.1 hypothetical protein -
NLS69_RS22470 (NLS69_22470) 4786168..4786593 - 426 WP_003114206.1 VOC family protein -
NLS69_RS22475 (NLS69_22475) 4786694..4787578 + 885 WP_016253805.1 LysR substrate-binding domain-containing protein -
NLS69_RS22480 (NLS69_22480) 4787551..4788504 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
NLS69_RS22485 (NLS69_22485) 4788725..4789159 + 435 WP_016253806.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T250912 WP_015503432.1 NZ_CP100653:c4785164-4784799 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT250912 WP_016561576.1 NZ_CP100653:c4784806-4784483 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References