Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1207771..1208393 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLS69_RS05685 Protein ID WP_033967229.1
Coordinates 1207771..1208085 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLS69_RS05690 Protein ID WP_023910258.1
Coordinates 1208088..1208393 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS05655 (NLS69_05655) 1202861..1203049 + 189 WP_003118306.1 Com family DNA-binding transcriptional regulator -
NLS69_RS05660 (NLS69_05660) 1203054..1203416 + 363 WP_023105983.1 hypothetical protein -
NLS69_RS05665 (NLS69_05665) 1203878..1204834 + 957 WP_225036329.1 site-specific integrase -
NLS69_RS05670 (NLS69_05670) 1204903..1205214 + 312 WP_225036327.1 outer membrane protein assembly factor BamE -
NLS69_RS05675 (NLS69_05675) 1205355..1206005 + 651 WP_225036326.1 BRCT domain-containing protein -
NLS69_RS05680 (NLS69_05680) 1206210..1207382 + 1173 WP_209408793.1 ATP-binding protein -
NLS69_RS05685 (NLS69_05685) 1207771..1208085 + 315 WP_033967229.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLS69_RS05690 (NLS69_05690) 1208088..1208393 + 306 WP_023910258.1 helix-turn-helix domain-containing protein Antitoxin
NLS69_RS05695 (NLS69_05695) 1208454..1208753 - 300 WP_225036325.1 hypothetical protein -
NLS69_RS05700 (NLS69_05700) 1208854..1209066 - 213 WP_225036324.1 hypothetical protein -
NLS69_RS05705 (NLS69_05705) 1209063..1210943 - 1881 WP_225036323.1 DNA cytosine methyltransferase -
NLS69_RS05710 (NLS69_05710) 1210940..1211419 - 480 WP_225036322.1 hypothetical protein -
NLS69_RS05715 (NLS69_05715) 1211429..1211668 - 240 WP_015649068.1 hypothetical protein -
NLS69_RS05720 (NLS69_05720) 1211665..1212291 - 627 WP_225036319.1 hypothetical protein -
NLS69_RS05725 (NLS69_05725) 1212342..1212659 - 318 WP_225036318.1 pyocin activator PrtN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1203878..1244134 40256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11772.54 Da        Isoelectric Point: 9.4385

>T250906 WP_033967229.1 NZ_CP100653:1207771-1208085 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLVY
DKASQEDLTADQKKVLRQIVENWR

Download         Length: 315 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11316.84 Da        Isoelectric Point: 7.2077

>AT250906 WP_023910258.1 NZ_CP100653:1208088-1208393 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References