Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3831015..3831612 Replicon chromosome
Accession NZ_CP100601
Organism Klebsiella pneumoniae strain WX17388

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag NLI98_RS18555 Protein ID WP_004142563.1
Coordinates 3831295..3831612 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag NLI98_RS18550 Protein ID WP_004142561.1
Coordinates 3831015..3831302 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLI98_RS18520 (3827096) 3827096..3827344 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NLI98_RS18525 (3827362) 3827362..3827703 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
NLI98_RS18530 (3827734) 3827734..3828849 - 1116 WP_172676897.1 MBL fold metallo-hydrolase -
NLI98_RS18535 (3829028) 3829028..3829609 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
NLI98_RS18540 (3829609) 3829609..3829977 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
NLI98_RS18545 (3830097) 3830097..3830750 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
NLI98_RS18550 (3831015) 3831015..3831302 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
NLI98_RS18555 (3831295) 3831295..3831612 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLI98_RS18560 (3831797) 3831797..3832840 - 1044 WP_088498345.1 DUF2157 domain-containing protein -
NLI98_RS18565 (3833510) 3833510..3834376 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
NLI98_RS18570 (3834485) 3834485..3835912 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T250881 WP_004142563.1 NZ_CP100601:c3831612-3831295 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT250881 WP_004142561.1 NZ_CP100601:c3831302-3831015 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References