Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731468..732243 Replicon chromosome
Accession NZ_CP100601
Organism Klebsiella pneumoniae strain WX17388

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A331A5C5
Locus tag NLI98_RS03605 Protein ID WP_019704987.1
Coordinates 731758..732243 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NLI98_RS03600 Protein ID WP_004150912.1
Coordinates 731468..731761 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLI98_RS03580 (726677) 726677..727279 - 603 WP_020802400.1 short chain dehydrogenase -
NLI98_RS03585 (727377) 727377..728288 + 912 WP_032440318.1 LysR family transcriptional regulator -
NLI98_RS03590 (728289) 728289..729437 - 1149 WP_088498406.1 PLP-dependent aspartate aminotransferase family protein -
NLI98_RS03595 (729448) 729448..730824 - 1377 WP_172676862.1 pyridoxal-phosphate dependent enzyme -
NLI98_RS03600 (731468) 731468..731761 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NLI98_RS03605 (731758) 731758..732243 + 486 WP_019704987.1 GNAT family N-acetyltransferase Toxin
NLI98_RS03610 (732941) 732941..733535 + 595 Protein_708 hypothetical protein -
NLI98_RS03615 (733632) 733632..733848 + 217 Protein_709 transposase -
NLI98_RS03625 (734526) 734526..735239 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 733632..733784 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17572.56 Da        Isoelectric Point: 8.5111

>T250874 WP_019704987.1 NZ_CP100601:731758-732243 [Klebsiella pneumoniae]
MISAPEPLNAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT250874 WP_004150912.1 NZ_CP100601:731468-731761 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331A5C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References