Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2654113..2654557 Replicon chromosome
Accession NZ_CP100596
Organism Enterococcus faecalis strain Chr-JH 2-2

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag NLG43_RS12990 Protein ID WP_002392696.1
Coordinates 2654414..2654557 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2654113..2654248 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG43_RS12975 2649660..2650373 - 714 WP_002354877.1 trehalose operon repressor -
NLG43_RS12980 2650635..2653379 + 2745 WP_002406717.1 glycosyl hydrolase family 65 protein -
NLG43_RS12985 2653394..2654044 + 651 WP_002354875.1 beta-phosphoglucomutase -
- 2654113..2654248 + 136 - - Antitoxin
NLG43_RS12990 2654414..2654557 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
NLG43_RS12995 2654789..2654932 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
NLG43_RS13000 2655163..2656134 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
NLG43_RS13005 2656309..2656743 - 435 WP_033918108.1 peptide-methionine (R)-S-oxide reductase MsrB -
NLG43_RS13010 2656876..2657430 - 555 WP_002396824.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T250861 WP_002392696.1 NZ_CP100596:c2654557-2654414 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 136 bp

>AT250861 NZ_CP100596:2654113-2654248 [Enterococcus faecalis]
TGAAAAGAGAGAGATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCTTTTGGATTAATTAAAAATA
ACCGTACTTGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACAGCTTTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References