Detailed information of TA system TA250858

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2590228..2590489
• Replicon: chromosome
• Accession: NZ_CP100596
• Organism: Enterococcus faecalis strain Chr-JH 2-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NLG43_RS12690
• Protein ID: WP_224561205.1
• Coordinates: 2590388..2590489 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2590228..2590439 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLG43_RS12665	2585912..2586865	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
NLG43_RS12670	2586904..2587659	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
NLG43_RS12675	2587656..2588621	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
NLG43_RS12680	2588618..2589565	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
NLG43_RS12685	2589750..2590202	+	453	WP_002378807.1	YueI family protein	-
-	2590228..2590439	+	212	-	-	Antitoxin
NLG43_RS12690	2590388..2590489	-	102	WP_224561205.1	putative holin-like toxin	Toxin
NLG43_RS12695	2590680..2592950	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
NLG43_RS12700	2593121..2593627	+	507	WP_002378810.1	cysteine hydrolase family protein	-
NLG43_RS12705	2593817..2594713	+	897	WP_002365354.1	YitT family protein	-
NLG43_RS12710	2594764..2595162	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T250858 WP_224561205.1 NZ_CP100596:c2590489-2590388 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT250858 NZ_CP100596:2590228-2590439 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin