Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3100600..3101249 Replicon chromosome
Accession NZ_CP100553
Organism Pseudomonas hydrolytica strain KHPS2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLY38_RS14430 Protein ID WP_254347854.1
Coordinates 3100600..3100944 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1H0F3K8
Locus tag NLY38_RS14435 Protein ID WP_074879837.1
Coordinates 3100941..3101249 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY38_RS14415 (NLY38_14415) 3096363..3098216 + 1854 WP_254347851.1 asparagine synthase (glutamine-hydrolyzing) -
NLY38_RS14420 (NLY38_14420) 3098303..3099502 + 1200 WP_254347852.1 MFS transporter -
NLY38_RS14425 (NLY38_14425) 3099516..3100442 + 927 WP_254347853.1 LysR family transcriptional regulator -
NLY38_RS14430 (NLY38_14430) 3100600..3100944 + 345 WP_254347854.1 toxin Toxin
NLY38_RS14435 (NLY38_14435) 3100941..3101249 + 309 WP_074879837.1 transcriptional regulator Antitoxin
NLY38_RS14440 (NLY38_14440) 3101608..3102120 + 513 WP_254347855.1 hypothetical protein -
NLY38_RS14445 (NLY38_14445) 3102117..3102491 + 375 WP_254347856.1 hypothetical protein -
NLY38_RS14450 (NLY38_14450) 3102481..3103176 + 696 WP_254347858.1 hypothetical protein -
NLY38_RS14455 (NLY38_14455) 3103238..3103627 + 390 WP_254347860.1 hypothetical protein -
NLY38_RS14460 (NLY38_14460) 3103726..3105345 + 1620 WP_254347862.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3058117..3123193 65076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13320.12 Da        Isoelectric Point: 9.8734

>T250853 WP_254347854.1 NZ_CP100553:3100600-3100944 [Pseudomonas hydrolytica]
MKASFVELSPFERNRNAYLDDDEYSLFQQMLLANPEAGPVITNSGGLRKIRFGSVRRSKGKRGGVRVIYYYWHSGLQFWL
FTLYDKDELDDLSSDQRRQLKALLEREVKARQAP

Download         Length: 345 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11575.36 Da        Isoelectric Point: 10.0927

>AT250853 WP_074879837.1 NZ_CP100553:3100941-3101249 [Pseudomonas hydrolytica]
MTKRDIFSELIEGFDDLAAAREGKRTLRTHKVEYKPIEPATGAEIVALREKLQMSQGVFAQAIHAKPATLKNWEQNRSKP
NDQATVLIRILSKHPELIRELA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0F3K8

References