Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3654967..3655508 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NLZ06_RS17575 Protein ID WP_000615976.1
Coordinates 3655230..3655508 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NLZ06_RS17570 Protein ID WP_000729704.1
Coordinates 3654967..3655227 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS17545 (3650750) 3650750..3651535 - 786 WP_000207557.1 putative lateral flagellar export/assembly protein LafU -
NLZ06_RS17550 (3651507) 3651507..3653219 + 1713 Protein_3434 flagellar biosynthesis protein FlhA -
NLZ06_RS17555 (3653324) 3653324..3653602 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NLZ06_RS17560 (3653595) 3653595..3653951 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NLZ06_RS17565 (3654008) 3654008..3654781 - 774 WP_000543897.1 C40 family peptidase -
NLZ06_RS17570 (3654967) 3654967..3655227 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NLZ06_RS17575 (3655230) 3655230..3655508 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NLZ06_RS17580 (3655664) 3655664..3656404 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NLZ06_RS17585 (3656375) 3656375..3657142 - 768 WP_000333380.1 class II glutamine amidotransferase -
NLZ06_RS17590 (3657348) 3657348..3657926 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T250836 WP_000615976.1 NZ_CP100544:3655230-3655508 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT250836 WP_000729704.1 NZ_CP100544:3654967-3655227 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References