Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3853321..3853862 Replicon chromosome
Accession NZ_CP100530
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name yafQ Uniprot ID A0A140NAP5
Locus tag NLZ08_RS19110 Protein ID WP_000615981.1
Coordinates 3853584..3853862 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NLZ08_RS19105 Protein ID WP_000729704.1
Coordinates 3853321..3853581 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS19085 (3849004) 3849004..3849789 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
NLZ08_RS19090 (3849761) 3849761..3851473 + 1713 Protein_3744 flagellar biosynthesis protein FlhA -
NLZ08_RS19095 (3851689) 3851689..3852186 - 498 WP_000006260.1 REP-associated tyrosine transposase RayT -
NLZ08_RS19100 (3852362) 3852362..3853135 - 774 WP_001353765.1 C40 family peptidase -
NLZ08_RS19105 (3853321) 3853321..3853581 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NLZ08_RS19110 (3853584) 3853584..3853862 + 279 WP_000615981.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NLZ08_RS19115 (3854018) 3854018..3854758 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NLZ08_RS19120 (3854729) 3854729..3855496 - 768 WP_000333379.1 class II glutamine amidotransferase -
NLZ08_RS19125 (3855702) 3855702..3856280 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10860.65 Da        Isoelectric Point: 10.0702

>T250794 WP_000615981.1 NZ_CP100530:3853584-3853862 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQSSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT250794 WP_000729704.1 NZ_CP100530:3853321-3853581 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MMG
PDB 4MMJ
PDB 4ML2
PDB 4ML0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References