Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1861015..1861517 Replicon chromosome
Accession NZ_CP100530
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag NLZ08_RS08800 Protein ID WP_000767826.1
Coordinates 1861263..1861517 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NLZ08_RS08795 Protein ID WP_001259255.1
Coordinates 1861015..1861266 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS08770 (1856193) 1856193..1857260 - 1068 WP_097749139.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NLZ08_RS08775 (1857260) 1857260..1858330 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
NLZ08_RS08780 (1858327) 1858327..1859631 - 1305 WP_001350692.1 histidinol dehydrogenase -
NLZ08_RS08785 (1859637) 1859637..1860536 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NLZ08_RS08790 (1860682) 1860682..1860732 - 51 WP_001364200.1 his operon leader peptide -
NLZ08_RS08795 (1861015) 1861015..1861266 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NLZ08_RS08800 (1861263) 1861263..1861517 + 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NLZ08_RS08805 (1861600) 1861600..1862424 + 825 WP_000754737.1 SDR family oxidoreductase -
NLZ08_RS08810 (1862470) 1862470..1863399 + 930 WP_000803363.1 LysR substrate-binding domain-containing protein -
NLZ08_RS08815 (1863614) 1863614..1863676 + 63 WP_010723108.1 membrane protein YoeI -
NLZ08_RS08820 (1863666) 1863666..1865024 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NLZ08_RS08825 (1865203) 1865203..1866261 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
NLZ08_RS08830 (1866275) 1866275..1866502 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T250783 WP_000767826.1 NZ_CP100530:1861263-1861517 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT250783 WP_001259255.1 NZ_CP100530:1861015-1861266 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References