Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 731388..732081 Replicon chromosome
Accession NZ_CP100530
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NLZ08_RS03540 Protein ID WP_000415584.1
Coordinates 731388..731684 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NLZ08_RS03545 Protein ID WP_000650107.1
Coordinates 731686..732081 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS03505 (726476) 726476..726790 - 315 WP_000958598.1 putative quinol monooxygenase -
NLZ08_RS03510 (726821) 726821..727402 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NLZ08_RS03515 (727721) 727721..728053 + 333 WP_000917684.1 DUF2645 family protein -
NLZ08_RS03520 (728099) 728099..729448 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NLZ08_RS03525 (729445) 729445..730104 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NLZ08_RS03530 (730256) 730256..730648 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NLZ08_RS03535 (730701) 730701..731183 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NLZ08_RS03540 (731388) 731388..731684 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NLZ08_RS03545 (731686) 731686..732081 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NLZ08_RS03550 (732214) 732214..733821 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NLZ08_RS03555 (733959) 733959..736217 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T250779 WP_000415584.1 NZ_CP100530:731388-731684 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT250779 WP_000650107.1 NZ_CP100530:731686-732081 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References