Detailed information of TA system TA250775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 204427..204649
• Replicon: chromosome
• Accession: NZ_CP100530
• Organism: Escherichia coli strain LH10-b-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: NLZ08_RS00940
• Protein ID: WP_001295224.1
• Coordinates: 204542..204649 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	204427..204485 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLZ08_RS00920	199868..200770	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
NLZ08_RS00925	200781..201764	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
NLZ08_RS00930	201761..202765	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
NLZ08_RS00935	202795..204066	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	204427..204485	-	59	-	-	Antitoxin
NLZ08_RS00940	204542..204649	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
NLZ08_RS00945	205025..205132	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
NLZ08_RS00950	205508..205615	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
NLZ08_RS00955	205991..206098	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	-
NLZ08_RS00960	206185..207864	-	1680	WP_097749325.1	cellulose biosynthesis protein BcsG	-
NLZ08_RS00965	207861..208052	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
NLZ08_RS00970	208063..208533	+	471	Protein_191	cell division protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T250775 WP_001295224.1 NZ_CP100530:204542-204649 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT250775 NZ_CP100530:c204485-204427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin