Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3737763..3738364 Replicon chromosome
Accession NC_014963
Organism Terriglobus saanensis SP1PR4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACIPR4_RS15065 Protein ID WP_013569520.1
Coordinates 3738086..3738364 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACIPR4_RS15060 Protein ID WP_013569519.1
Coordinates 3737763..3738077 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIPR4_RS15035 3733387..3733827 - 441 WP_013569514.1 helix-turn-helix transcriptional regulator -
ACIPR4_RS15040 3733934..3734980 + 1047 WP_013569515.1 SDR family NAD(P)-dependent oxidoreductase -
ACIPR4_RS15045 3734984..3736204 - 1221 WP_013569516.1 J domain-containing protein -
ACIPR4_RS15050 3736214..3736834 - 621 WP_013569517.1 hypothetical protein -
ACIPR4_RS15055 3736834..3737751 - 918 WP_013569518.1 Fpg/Nei family DNA glycosylase -
ACIPR4_RS15060 3737763..3738077 - 315 WP_013569519.1 HigA family addiction module antidote protein Antitoxin
ACIPR4_RS15065 3738086..3738364 - 279 WP_013569520.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACIPR4_RS22785 3738417..3738587 - 171 WP_013569521.1 hypothetical protein -
ACIPR4_RS15070 3738724..3740640 - 1917 WP_013569522.1 molecular chaperone DnaK -
ACIPR4_RS15075 3740792..3741868 + 1077 WP_013569523.1 hypothetical protein -
ACIPR4_RS15080 3741880..3742899 - 1020 WP_013569524.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10538.05 Da        Isoelectric Point: 10.2158

>T25074 WP_013569520.1 NC_014963:c3738364-3738086 [Terriglobus saanensis SP1PR4]
VILSFRDRAVETLFKEGRHKKFGSITSAALRRLAALNAAVDLEALRFPPANRLEVLRGDRTGQHSIRINDQYRICFRWTK
AGAEDVEIVDYH

Download         Length: 279 bp

>T25074 NC_014963:c3738364-3738086 [Terriglobus saanensis SP1PR4]
GTGATTCTCTCTTTTCGCGACCGTGCAGTGGAGACGCTGTTCAAAGAAGGTCGTCACAAGAAGTTTGGCTCTATTACTTC
GGCAGCGCTTCGCAGATTGGCTGCTCTTAATGCGGCAGTTGATCTGGAGGCGCTTCGTTTTCCTCCAGCGAATCGTCTGG
AAGTGCTTCGTGGAGACCGTACTGGTCAGCATAGTATTCGCATCAATGATCAGTACCGAATATGCTTCCGATGGACGAAG
GCCGGGGCAGAAGACGTTGAAATCGTGGATTATCACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11550.32 Da        Isoelectric Point: 10.3019

>AT25074 WP_013569519.1 NC_014963:c3738077-3737763 [Terriglobus saanensis SP1PR4]
MSIPRDPNHPGFPVHPGSILREDFLVPLNLSANALSIALRVPSTRITEIVAERRGITADTAYRLAAYFGGPASFWMNLQA
NYELAITYKQAVSVINKEVRRRVA

Download         Length: 315 bp

>AT25074 NC_014963:c3738077-3737763 [Terriglobus saanensis SP1PR4]
ATGTCGATTCCAAGAGATCCAAATCATCCCGGCTTCCCAGTTCATCCAGGTTCGATTCTGCGTGAAGATTTCCTTGTGCC
GCTGAATCTGAGCGCAAATGCATTGTCGATCGCGCTCCGCGTGCCTTCCACGCGCATCACCGAGATCGTCGCCGAGCGTC
GTGGAATTACTGCAGATACTGCTTATCGGCTTGCCGCATACTTTGGCGGGCCAGCGTCGTTCTGGATGAATCTCCAGGCC
AATTATGAACTCGCGATTACTTATAAACAGGCCGTCTCTGTCATCAACAAAGAAGTACGTCGCCGCGTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References