Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3406456..3407043 Replicon chromosome
Accession NC_014960
Organism Anaerolinea thermophila UNI-1

Toxin (Protein)


Gene name graT Uniprot ID E8N2U2
Locus tag ANT_RS15290 Protein ID WP_013561433.1
Coordinates 3406762..3407043 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ANT_RS15285 Protein ID WP_013561432.1
Coordinates 3406456..3406752 (-) Length 99 a.a.

Genomic Context

ANT_RS15295ANT_RS15305ANT_RS15255ANT_RS16705ANT_RS16710ANT_RS15270ANT_RS15275ANT_RS15280ANT_RS15285ANT_RS15290ANT_RS15300ANT_RS15310
Location: 3407269..3409134 (1866 bp)
Type: Others
Protein ID: WP_013561434.1
Location: 3410741..3411505 (765 bp)
Type: Others
Protein ID: WP_013561436.1
Location: 3401563..3401868 (306 bp)
Type: Others
Protein ID: WP_013561426.1
Location: 3401921..3402745 (825 bp)
Type: Others
Protein ID: WP_013561427.1
Location: 3402897..3403301 (405 bp)
Type: Others
Protein ID: WP_013561428.1
Location: 3403484..3404581 (1098 bp)
Type: Others
Protein ID: WP_013561429.1
Location: 3404848..3405663 (816 bp)
Type: Others
Protein ID: WP_013561430.1
Location: 3405762..3406343 (582 bp)
Type: Others
Protein ID: WP_013561431.1
Location: 3406456..3406752 (297 bp)
Type: Antitoxin
Protein ID: WP_013561432.1
Location: 3406762..3407043 (282 bp)
Type: Toxin
Protein ID: WP_013561433.1
Location: 3409425..3410660 (1236 bp)
Type: Others
Protein ID: WP_013561435.1
Location: 3411556..3411729 (174 bp)
Type: Others
Protein ID: WP_013561437.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ANT_RS152553401563..3401868-306WP_013561426.1hypothetical protein-
ANT_RS167053401921..3402745-825WP_013561427.1CPBP family intramembrane metalloprotease-
ANT_RS167103402897..3403301-405WP_013561428.1hypothetical protein-
ANT_RS152703403484..3404581-1098WP_013561429.1phosphoserine transaminase-
ANT_RS152753404848..3405663-816WP_013561430.1ATP-dependent sacrificial sulfur transferase LarE-
ANT_RS152803405762..3406343-582WP_013561431.1HD domain-containing protein-
ANT_RS152853406456..3406752-297WP_013561432.1HigA family addiction module antidote proteinAntitoxin
ANT_RS152903406762..3407043-282WP_013561433.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ANT_RS152953407269..3409134+1866WP_013561434.1molecular chaperone DnaK-
ANT_RS153003409425..3410660-1236WP_013561435.1aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme-
ANT_RS153053410741..3411505+765WP_013561436.1SDR family oxidoreductase-
ANT_RS153103411556..3411729-174WP_013561437.14Fe-4S binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10901.29 Da        Isoelectric Point: 6.8703

>T25073 WP_013561433.1 NC_014960:c3407043-3406762 [Anaerolinea thermophila UNI-1]
VIKSFRDRSTESLFHGERHPSLPPNLQRIALRKLLILDAAADLDDLRVPPGNHLEKLRGDREGQYSIRINDRYRLCFVWQ
DGDAYEVEITNYH

Download         Length: 282 bp

>T25073 NC_014960:c3407043-3406762 [Anaerolinea thermophila UNI-1]
GTGATTAAGTCCTTCCGCGATCGCTCTACCGAGAGCCTGTTTCACGGAGAACGGCATCCCTCTCTGCCGCCCAATCTGCA
AAGAATTGCCTTGCGCAAACTGCTCATCCTGGATGCCGCCGCCGATCTCGATGACCTGCGTGTTCCGCCCGGCAATCACC
TGGAGAAACTGCGCGGCGACCGCGAAGGACAGTACAGCATCCGTATCAACGACCGTTACCGTCTTTGCTTTGTCTGGCAG
GACGGAGACGCCTATGAAGTTGAAATTACCAATTACCACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11138.88 Da        Isoelectric Point: 5.1425

>AT25073 WP_013561432.1 NC_014960:c3406752-3406456 [Anaerolinea thermophila UNI-1]
MTREIPPIHPGEILLEEFLKPLGISQNALARALRVPPDRINAIVQGKRSITADTALRLARAFGTTPQFWLNLQARYDLDV
AQDRLEEQIEREVLPLIE

Download         Length: 297 bp

>AT25073 NC_014960:c3406752-3406456 [Anaerolinea thermophila UNI-1]
ATGACCCGCGAAATTCCGCCTATCCATCCCGGTGAGATTTTACTGGAAGAGTTTCTCAAGCCGTTGGGCATCAGCCAGAA
CGCCCTGGCTCGCGCTCTGCGCGTTCCGCCCGACCGTATCAATGCCATTGTGCAGGGCAAGCGCAGTATCACGGCAGATA
CTGCTTTGCGTCTGGCGCGCGCTTTTGGCACAACGCCTCAGTTCTGGCTGAATTTGCAGGCGCGTTACGACCTGGATGTT
GCGCAGGATCGTCTGGAAGAGCAGATTGAGCGCGAGGTGCTTCCTTTGATTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE8N2U2

Antitoxin

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Source
ID
Structure
No matching records found

References