Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2387773..2388379 Replicon chromosome
Accession NC_014960
Organism Anaerolinea thermophila UNI-1

Toxin (Protein)


Gene name higB Uniprot ID E8MXT5
Locus tag ANT_RS10680 Protein ID WP_013560536.1
Coordinates 2387773..2388093 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ANT_RS10685 Protein ID WP_013560537.1
Coordinates 2388086..2388379 (+) Length 98 a.a.

Genomic Context

ANT_RS10655ANT_RS10660ANT_RS10665ANT_RS10670ANT_RS10680ANT_RS10685ANT_RS10640ANT_RS17385ANT_RS10645ANT_RS16475ANT_RS17390ANT_RS16480ANT_RS16485ANT_RS10695ANT_RS10700ANT_RS10705
Location: 2384975..2386123 (1149 bp)
Type: Others
Protein ID: WP_172634617.1
Location: 2386120..2386629 (510 bp)
Type: Others
Protein ID: WP_013560532.1
Location: 2386798..2387034 (237 bp)
Type: Others
Protein ID: WP_013560533.1
Location: 2387015..2387314 (300 bp)
Type: Others
Protein ID: WP_013560534.1
Location: 2387773..2388093 (321 bp)
Type: Toxin
Protein ID: WP_013560536.1
Location: 2388086..2388379 (294 bp)
Type: Antitoxin
Protein ID: WP_013560537.1
Location: 2382982..2383416 (435 bp)
Type: Others
Protein ID: WP_041454944.1
Location: 2383490..2383630 (141 bp)
Type: Others
Protein ID: WP_013560527.1
Location: 2383706..2384158 (453 bp)
Type: Others
Protein ID: WP_013560528.1
Location: 2384160..2384573 (414 bp)
Type: Others
Protein ID: WP_013560529.1
Location: 2384591..2384755 (165 bp)
Type: Others
Protein ID: WP_013560530.1
Location: 2387283..2387687 (405 bp)
Type: Others
Protein ID: WP_162787686.1
Location: 2388384..2389256 (873 bp)
Type: Others
Protein ID: WP_013560538.1
Location: 2389246..2390196 (951 bp)
Type: Others
Protein ID: WP_172634618.1
Location: 2390511..2391377 (867 bp)
Type: Others
Protein ID: WP_013560540.1
Location: 2391476..2392399 (924 bp)
Type: Others
Protein ID: WP_013560541.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ANT_RS106402382982..2383416-435WP_041454944.1hypothetical protein-
ANT_RS173852383490..2383630-141WP_013560527.1hypothetical protein-
ANT_RS106452383706..2384158-453WP_013560528.1hypothetical protein-
ANT_RS164752384160..2384573-414WP_013560529.1hypothetical protein-
ANT_RS173902384591..2384755-165WP_013560530.1hypothetical protein-
ANT_RS106552384975..2386123+1149WP_172634617.1ImmA/IrrE family metallo-endopeptidase-
ANT_RS106602386120..2386629+510WP_013560532.1DUF4411 family protein-
ANT_RS106652386798..2387034+237WP_013560533.1DUF4160 domain-containing protein-
ANT_RS106702387015..2387314+300WP_013560534.1DUF2442 domain-containing protein-
ANT_RS164802387283..2387687-405WP_162787686.1A24 family peptidase-
ANT_RS106802387773..2388093+321WP_013560536.1hypothetical proteinToxin
ANT_RS106852388086..2388379+294WP_013560537.1helix-turn-helix domain-containing proteinAntitoxin
ANT_RS164852388384..2389256-873WP_013560538.1N-acetylmuramoyl-L-alanine amidase-
ANT_RS106952389246..2390196-951WP_172634618.1CAP domain-containing protein-
ANT_RS107002390511..2391377-867WP_013560540.1hypothetical protein-
ANT_RS107052391476..2392399-924WP_013560541.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2375439..242430548866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-84)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12552.41 Da        Isoelectric Point: 8.5130

>T25072 WP_013560536.1 NC_014960:2387773-2388093 [Anaerolinea thermophila UNI-1]
MHFIETSVFTRRILELMSDDEYRALQIFLSTRPDAGDIIPGSGGLRKVRWHTGTTGKRGGIRLIYYWVVRDDTILLLFAF
RKNERSDLTPEQIRILRRIVEEEYHE

Download         Length: 321 bp

>T25072 NC_014960:2387773-2388093 [Anaerolinea thermophila UNI-1]
ATGCACTTCATCGAGACTTCCGTCTTCACCCGTCGAATTCTGGAATTAATGAGCGATGATGAATATCGAGCCCTGCAAAT
CTTTCTGAGCACCAGACCAGATGCAGGAGACATTATTCCGGGAAGCGGTGGACTTCGTAAAGTACGATGGCATACTGGTA
CCACAGGTAAACGTGGCGGCATTCGGCTGATTTATTACTGGGTGGTTCGTGACGATACCATACTGCTTTTGTTCGCTTTC
CGAAAAAATGAACGTTCCGATCTAACCCCAGAACAGATTCGAATCCTGCGCCGAATTGTCGAGGAGGAATACCATGAATA
A

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11014.68 Da        Isoelectric Point: 11.0713

>AT25072 WP_013560537.1 NC_014960:2388086-2388379 [Anaerolinea thermophila UNI-1]
MNNETFTELLSSVQEGADILRGRRPPSRVFDINFQDVKAIRERLGLSQRQFAALMGVSIDTLQNWEQNRRKPRGAARTLL
LIAAKHPETILDILKTA

Download         Length: 294 bp

>AT25072 NC_014960:2388086-2388379 [Anaerolinea thermophila UNI-1]
ATGAATAACGAAACTTTCACTGAATTACTCTCCAGCGTGCAGGAAGGGGCTGACATTCTTCGCGGACGACGCCCTCCTTC
TCGCGTTTTTGACATTAACTTCCAGGACGTCAAGGCGATCCGTGAGCGCCTGGGGCTTTCACAGCGCCAATTTGCCGCAT
TGATGGGCGTGAGCATTGACACCCTGCAAAACTGGGAACAAAACCGCCGTAAACCCCGTGGAGCAGCCAGAACACTGCTT
CTCATTGCCGCCAAACATCCCGAAACCATTCTGGACATCCTGAAAACTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE8MXT5

Antitoxin

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Source
ID
Structure
No matching records found

References