Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5343666..5344268 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NLZ13_RS25975 Protein ID WP_000897305.1
Coordinates 5343957..5344268 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLZ13_RS25970 Protein ID WP_000356397.1
Coordinates 5343666..5343956 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS25945 (5339613) 5339613..5340515 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NLZ13_RS25950 (5340512) 5340512..5341147 + 636 WP_000829031.1 formate dehydrogenase cytochrome b556 subunit -
NLZ13_RS25955 (5341144) 5341144..5342073 + 930 WP_000027691.1 formate dehydrogenase accessory protein FdhE -
NLZ13_RS25960 (5342403) 5342403..5342645 - 243 WP_001086385.1 protein YiiF -
NLZ13_RS25965 (5342864) 5342864..5343082 - 219 WP_001313440.1 CopG family transcriptional regulator -
NLZ13_RS25970 (5343666) 5343666..5343956 - 291 WP_000356397.1 NadS family protein Antitoxin
NLZ13_RS25975 (5343957) 5343957..5344268 - 312 WP_000897305.1 hypothetical protein Toxin
NLZ13_RS25980 (5344497) 5344497..5345405 + 909 WP_023155176.1 alpha/beta hydrolase -
NLZ13_RS25985 (5345573) 5345573..5346487 - 915 WP_191663692.1 transposase -
NLZ13_RS25990 (5346497) 5346497..5347387 - 891 Protein_5095 hypothetical protein -
NLZ13_RS25995 (5347798) 5347798..5348739 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
NLZ13_RS26000 (5348784) 5348784..5349221 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T250691 WP_000897305.1 NZ_CP100500:c5344268-5343957 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT250691 WP_000356397.1 NZ_CP100500:c5343956-5343666 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References