250685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4396341..4396882 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yafQ Uniprot ID U9XF38
Locus tag NLZ13_RS21675 Protein ID WP_001695460.1
Coordinates 4396604..4396882 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NLZ13_RS21670 Protein ID WP_000729704.1
Coordinates 4396341..4396601 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS21650 (4391923) 4391923..4392708 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
NLZ13_RS21655 (4392680) 4392680..4394392 + 1713 Protein_4255 flagellar biosynthesis protein FlhA -
NLZ13_RS21660 (4394608) 4394608..4395105 - 498 WP_000006265.1 REP-associated tyrosine transposase RayT -
NLZ13_RS21665 (4395382) 4395382..4396131 - 750 WP_001695461.1 C40 family peptidase -
NLZ13_RS21670 (4396341) 4396341..4396601 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NLZ13_RS21675 (4396604) 4396604..4396882 + 279 WP_001695460.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NLZ13_RS21680 (4397038) 4397038..4397778 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NLZ13_RS21685 (4397749) 4397749..4398516 - 768 WP_000333379.1 class II glutamine amidotransferase -
NLZ13_RS21690 (4398722) 4398722..4399300 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4395382..4405103 9721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T250685 WP_001695460.1 NZ_CP100500:4396604-4396882 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYIMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT250685 WP_000729704.1 NZ_CP100500:4396341-4396601 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XF38

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References