250675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2180581..2181083 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NLZ13_RS10645 Protein ID WP_000767829.1
Coordinates 2180829..2181083 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NLZ13_RS10640 Protein ID WP_001259255.1
Coordinates 2180581..2180832 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS10615 (2175759) 2175759..2176826 - 1068 WP_021541051.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NLZ13_RS10620 (2176826) 2176826..2177896 - 1071 WP_000108953.1 histidinol-phosphate transaminase -
NLZ13_RS10625 (2177893) 2177893..2179197 - 1305 WP_064186579.1 histidinol dehydrogenase -
NLZ13_RS10630 (2179203) 2179203..2180102 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NLZ13_RS10635 (2180248) 2180248..2180298 - 51 WP_001364200.1 his operon leader peptide -
NLZ13_RS10640 (2180581) 2180581..2180832 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NLZ13_RS10645 (2180829) 2180829..2181083 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NLZ13_RS10650 (2181166) 2181166..2181990 + 825 WP_000754737.1 SDR family oxidoreductase -
NLZ13_RS10655 (2182036) 2182036..2182965 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NLZ13_RS10660 (2183180) 2183180..2183242 + 63 WP_010723108.1 membrane protein YoeI -
NLZ13_RS10665 (2183232) 2183232..2184590 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NLZ13_RS10670 (2184769) 2184769..2185729 + 961 Protein_2094 YeeE/YedE family protein -
NLZ13_RS10675 (2185743) 2185743..2185970 + 228 WP_000985277.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T250675 WP_000767829.1 NZ_CP100500:2180829-2181083 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT250675 WP_001259255.1 NZ_CP100500:2180581-2180832 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References