250669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 665208..666007 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NLZ13_RS03255 Protein ID WP_000347273.1
Coordinates 665208..665672 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NLZ13_RS03260 Protein ID WP_001307405.1
Coordinates 665672..666007 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS03225 (660209) 660209..660643 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NLZ13_RS03230 (660661) 660661..661539 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NLZ13_RS03235 (661529) 661529..662308 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NLZ13_RS03240 (662319) 662319..662792 - 474 WP_001626031.1 PTS N-acetylgalactosamine transporter subunit IIB -
NLZ13_RS03245 (662815) 662815..664095 - 1281 WP_000681939.1 tagatose-bisphosphate aldolase subunit KbaZ -
NLZ13_RS03250 (664344) 664344..665153 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NLZ13_RS03255 (665208) 665208..665672 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NLZ13_RS03260 (665672) 665672..666007 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NLZ13_RS03265 (666156) 666156..667727 - 1572 WP_001273763.1 galactarate dehydratase -
NLZ13_RS03270 (668102) 668102..669436 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NLZ13_RS03275 (669452) 669452..670222 + 771 WP_001058233.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T250669 WP_000347273.1 NZ_CP100500:c665672-665208 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT250669 WP_001307405.1 NZ_CP100500:c666007-665672 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References