Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4892534..4893136 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NLZ16_RS23400 Protein ID WP_000897305.1
Coordinates 4892825..4893136 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLZ16_RS23395 Protein ID WP_000356395.1
Coordinates 4892534..4892824 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS23360 (4888158) 4888158..4889060 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NLZ16_RS23365 (4889057) 4889057..4889692 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NLZ16_RS23370 (4889689) 4889689..4890618 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NLZ16_RS23375 (4890800) 4890800..4891042 - 243 WP_001309881.1 CopG family transcriptional regulator -
NLZ16_RS23380 (4891261) 4891261..4891479 - 219 WP_001295676.1 CopG family transcriptional regulator -
NLZ16_RS23385 (4891898) 4891898..4892176 - 279 WP_001315112.1 hypothetical protein -
NLZ16_RS23390 (4892228) 4892228..4892449 - 222 WP_001550354.1 hypothetical protein -
NLZ16_RS23395 (4892534) 4892534..4892824 - 291 WP_000356395.1 NadS family protein Antitoxin
NLZ16_RS23400 (4892825) 4892825..4893136 - 312 WP_000897305.1 hypothetical protein Toxin
NLZ16_RS23405 (4893365) 4893365..4894273 + 909 WP_001550353.1 alpha/beta hydrolase -
NLZ16_RS23410 (4894441) 4894441..4895355 - 915 WP_109553727.1 transposase -
NLZ16_RS23415 (4895368) 4895368..4896255 - 888 Protein_4579 hypothetical protein -
NLZ16_RS23420 (4896671) 4896671..4897612 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NLZ16_RS23425 (4897657) 4897657..4898094 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T250632 WP_000897305.1 NZ_CP100486:c4893136-4892825 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT250632 WP_000356395.1 NZ_CP100486:c4892824-4892534 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References