Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1994028..1994530 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NLZ16_RS09365 Protein ID WP_000767829.1
Coordinates 1994276..1994530 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A377LDC7
Locus tag NLZ16_RS09360 Protein ID WP_001259257.1
Coordinates 1994028..1994279 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS09335 (1989206) 1989206..1990273 - 1068 WP_000080080.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NLZ16_RS09340 (1990273) 1990273..1991343 - 1071 WP_000108953.1 histidinol-phosphate transaminase -
NLZ16_RS09345 (1991340) 1991340..1992644 - 1305 WP_001468917.1 histidinol dehydrogenase -
NLZ16_RS09350 (1992650) 1992650..1993549 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NLZ16_RS09355 (1993695) 1993695..1993745 - 51 WP_001364200.1 his operon leader peptide -
NLZ16_RS09360 (1994028) 1994028..1994279 + 252 WP_001259257.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NLZ16_RS09365 (1994276) 1994276..1994530 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NLZ16_RS09370 (1994613) 1994613..1995437 + 825 WP_000754737.1 SDR family oxidoreductase -
NLZ16_RS09375 (1995483) 1995483..1996412 + 930 WP_000803350.1 LysR substrate-binding domain-containing protein -
NLZ16_RS09380 (1996627) 1996627..1996689 + 63 WP_010723108.1 membrane protein YoeI -
NLZ16_RS09385 (1996679) 1996679..1998037 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T250616 WP_000767829.1 NZ_CP100486:1994276-1994530 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9306.64 Da        Isoelectric Point: 5.8289

>AT250616 WP_001259257.1 NZ_CP100486:1994028-1994279 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIK

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A377LDC7

References