250600

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2024790..2025450 Replicon chromosome
Accession NZ_CP100482
Organism Klebsiella grimontii strain LH87-a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLZ17_RS09650 Protein ID WP_154975687.1
Coordinates 2024790..2025143 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag NLZ17_RS09655 Protein ID WP_004132739.1
Coordinates 2025148..2025450 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ17_RS09625 (NLZ17_09625) 2020174..2020941 - 768 WP_154975688.1 molybdopterin-dependent oxidoreductase -
NLZ17_RS09630 (NLZ17_09630) 2020931..2021539 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
NLZ17_RS09635 (NLZ17_09635) 2021554..2022180 - 627 WP_004132731.1 hypothetical protein -
NLZ17_RS09640 (NLZ17_09640) 2022320..2022988 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
NLZ17_RS09645 (NLZ17_09645) 2022988..2024406 + 1419 WP_064411585.1 heavy metal sensor histidine kinase -
NLZ17_RS09650 (NLZ17_09650) 2024790..2025143 + 354 WP_154975687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ17_RS09655 (NLZ17_09655) 2025148..2025450 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
NLZ17_RS09660 (NLZ17_09660) 2025644..2025847 + 204 Protein_1894 hypothetical protein -
NLZ17_RS09665 (NLZ17_09665) 2025848..2026180 + 333 WP_024359977.1 type II toxin-antitoxin system PemK/MazF family toxin -
NLZ17_RS09675 (NLZ17_09675) 2026503..2027960 + 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
NLZ17_RS09685 (NLZ17_09685) 2028990..2030444 - 1455 WP_024359975.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13614.64 Da        Isoelectric Point: 10.3329

>T250600 WP_154975687.1 NZ_CP100482:2024790-2025143 [Klebsiella grimontii]
VWMIKTTDTFERWFTSFNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFGPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT250600 WP_004132739.1 NZ_CP100482:2025148-2025450 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References