Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733711..734486 Replicon chromosome
Accession NZ_CP100478
Organism Klebsiella pneumoniae strain LH99-d

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NLZ18_RS03705 Protein ID WP_048255216.1
Coordinates 734001..734486 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NLZ18_RS03700 Protein ID WP_004150912.1
Coordinates 733711..734004 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ18_RS03680 (728920) 728920..729522 - 603 WP_032442511.1 short chain dehydrogenase -
NLZ18_RS03685 (729620) 729620..730531 + 912 WP_004188550.1 LysR family transcriptional regulator -
NLZ18_RS03690 (730532) 730532..731680 - 1149 WP_020316731.1 PLP-dependent aspartate aminotransferase family protein -
NLZ18_RS03695 (731691) 731691..733067 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
NLZ18_RS03700 (733711) 733711..734004 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NLZ18_RS03705 (734001) 734001..734486 + 486 WP_048255216.1 GNAT family N-acetyltransferase Toxin
NLZ18_RS03710 (735184) 735184..735777 + 594 Protein_727 hypothetical protein -
NLZ18_RS03715 (735874) 735874..736090 + 217 Protein_728 transposase -
NLZ18_RS03725 (736931) 736931..737644 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735874..736026 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.62 Da        Isoelectric Point: 8.8818

>T250584 WP_048255216.1 NZ_CP100478:734001-734486 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVNKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT250584 WP_004150912.1 NZ_CP100478:733711-734004 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References