Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1360164..1360807 Replicon chromosome
Accession NC_014922
Organism Haemophilus influenzae F3047

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HICON_RS06675 Protein ID WP_006995912.1
Coordinates 1360469..1360807 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HICON_RS06670 Protein ID WP_006995911.1
Coordinates 1360164..1360472 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HICON_RS06640 1355796..1356908 + 1113 WP_006995904.1 iron-sulfur cluster carrier protein ApbC -
HICON_RS06645 1357131..1357400 + 270 WP_006995905.1 hypothetical protein -
HICON_RS06650 1357400..1357753 + 354 WP_006995906.1 type II toxin-antitoxin system PemK/MazF family toxin -
HICON_RS06655 1357792..1358454 - 663 WP_006995907.1 NAD(P)H-dependent oxidoreductase -
HICON_RS06660 1358568..1359242 + 675 WP_006995908.1 N-acylneuraminate cytidylyltransferase -
HICON_RS10245 1359314..1359833 + 520 Protein_1281 DDE-type integrase/transposase/recombinase -
HICON_RS06670 1360164..1360472 - 309 WP_006995911.1 helix-turn-helix domain-containing protein Antitoxin
HICON_RS06675 1360469..1360807 - 339 WP_006995912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HICON_RS06680 1361398..1363590 - 2193 WP_006995913.1 DUF927 domain-containing protein -
HICON_RS06685 1363578..1363970 - 393 WP_006995914.1 hypothetical protein -
HICON_RS06690 1363963..1364646 - 684 WP_006995915.1 hypothetical protein -
HICON_RS06695 1364633..1364836 - 204 WP_006995916.1 hypothetical protein -
HICON_RS06700 1364826..1365197 - 372 WP_006995917.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-80)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.05 Da        Isoelectric Point: 9.2488

>T25058 WP_006995912.1 NC_014922:c1360807-1360469 [Haemophilus influenzae F3047]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENPEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Download         Length: 339 bp

>T25058 NC_014922:c1360807-1360469 [Haemophilus influenzae F3047]
GTGAAATTATCATTTATTGAATTACCGCCCTTTGAGCGTTACAGAAAAGCACATTTATCTGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCTGAAAAGGGAGACGTGATACAAAATGCTGGTGGCTTGCGGAAAATTAGGATTGCCG
ATAGTGAAAGAAATAAAGGGAAACGAGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCGCAGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11550.34 Da        Isoelectric Point: 9.9619

>AT25058 WP_006995911.1 NC_014922:c1360472-1360164 [Haemophilus influenzae F3047]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Download         Length: 309 bp

>AT25058 NC_014922:c1360472-1360164 [Haemophilus influenzae F3047]
ATGAGTAAATTATTTGATGAGCTTATAGAAGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTCAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACAGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCCGTTTTTGCGCAGAAGTTACGAACTAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGGAAAACCAAACCTAGCGCA
CACGCCTCCTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTCATCGCAGGGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References