25056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 606947..608295 Replicon chromosome
Accession NC_014922
Organism Haemophilus influenzae F3047

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag HICON_RS03025 Protein ID WP_013527393.1
Coordinates 607264..608295 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag HICON_RS03020 Protein ID WP_013527392.1
Coordinates 606947..607267 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HICON_RS02980 602369..602647 + 279 WP_005661211.1 cell division protein FtsB -
HICON_RS02985 602647..603324 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
HICON_RS02990 603321..603797 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
HICON_RS02995 604102..604536 - 435 WP_013526377.1 D-tyrosyl-tRNA(Tyr) deacylase -
HICON_RS03000 604533..604973 - 441 WP_013527390.1 FMN-binding protein MioC -
HICON_RS03005 605070..605288 - 219 WP_005650820.1 cell division protein ZapB -
HICON_RS03010 605450..606451 + 1002 WP_013527391.1 class II fructose-bisphosphatase -
HICON_RS03015 606651..606959 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
HICON_RS03020 606947..607267 + 321 WP_013527392.1 type II toxin-antitoxin system HipA family toxin Antitoxin
HICON_RS03025 607264..608295 + 1032 WP_013527393.1 type II toxin-antitoxin system HipA family toxin Toxin
HICON_RS03030 608378..610036 - 1659 WP_013527394.1 thiol reductant ABC exporter subunit CydC -
HICON_RS03035 610029..611774 - 1746 WP_013527395.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39809.38 Da        Isoelectric Point: 6.7269

>T25056 WP_013527393.1 NC_014922:607264-608295 [Haemophilus influenzae F3047]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKTMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGGDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T25056 NC_014922:607264-608295 [Haemophilus influenzae F3047]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTGCATTA
TCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACCGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAAACAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTAAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGGTGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCGTTACTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12452.13 Da        Isoelectric Point: 6.3254

>AT25056 WP_013527392.1 NC_014922:606947-607267 [Haemophilus influenzae F3047]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPISLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT25056 NC_014922:606947-607267 [Haemophilus influenzae F3047]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGATCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References