Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2071682..2072201 Replicon chromosome
Accession NZ_CP100432
Organism Streptococcus suis T15

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NLY75_RS10425 Protein ID WP_013730620.1
Coordinates 2071682..2071939 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NLY75_RS10430 Protein ID WP_002939010.1
Coordinates 2071941..2072201 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY75_RS10410 (NLY75_10410) 2068155..2069885 - 1731 WP_023371683.1 membrane protein -
NLY75_RS10415 (NLY75_10415) 2070248..2071120 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NLY75_RS10420 (NLY75_10420) 2071139..2071609 - 471 WP_023371685.1 DUF1697 domain-containing protein -
NLY75_RS10425 (NLY75_10425) 2071682..2071939 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NLY75_RS10430 (NLY75_10430) 2071941..2072201 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLY75_RS10435 (NLY75_10435) 2072277..2072732 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
NLY75_RS10440 (NLY75_10440) 2072739..2073068 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
NLY75_RS10445 (NLY75_10445) 2073058..2073345 - 288 WP_023371687.1 hypothetical protein -
NLY75_RS10450 (NLY75_10450) 2073443..2073811 - 369 WP_023371689.1 hypothetical protein -
NLY75_RS10455 (NLY75_10455) 2073804..2074373 - 570 WP_012775700.1 ribonuclease M5 -
NLY75_RS10460 (NLY75_10460) 2074357..2075139 - 783 WP_012028536.1 TatD family hydrolase -
NLY75_RS10465 (NLY75_10465) 2075246..2075383 - 138 WP_002939016.1 50S ribosomal protein L34 -
NLY75_RS10470 (NLY75_10470) 2075626..2076712 + 1087 Protein_2027 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2075795..2076712 917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T250559 WP_013730620.1 NZ_CP100432:c2071939-2071682 [Streptococcus suis T15]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT250559 WP_002939010.1 NZ_CP100432:c2072201-2071941 [Streptococcus suis T15]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References