Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2121626..2122145 Replicon chromosome
Accession NZ_CP100431
Organism Streptococcus suis strain 1521251

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NLY77_RS10575 Protein ID WP_013730620.1
Coordinates 2121626..2121883 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NLY77_RS10580 Protein ID WP_002939010.1
Coordinates 2121885..2122145 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY77_RS10560 (NLY77_10560) 2118097..2119827 - 1731 WP_009910905.1 membrane protein -
NLY77_RS10565 (NLY77_10565) 2120190..2121062 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NLY77_RS10570 (NLY77_10570) 2121082..2121612 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NLY77_RS10575 (NLY77_10575) 2121626..2121883 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NLY77_RS10580 (NLY77_10580) 2121885..2122145 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLY77_RS10585 (NLY77_10585) 2122221..2122676 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
NLY77_RS10590 (NLY77_10590) 2122680..2123048 - 369 WP_013730622.1 hypothetical protein -
NLY77_RS10595 (NLY77_10595) 2123041..2123610 - 570 WP_022540720.1 ribonuclease M5 -
NLY77_RS10600 (NLY77_10600) 2123594..2124376 - 783 WP_002939015.1 TatD family hydrolase -
NLY77_RS10605 (NLY77_10605) 2124484..2124621 - 138 WP_002939016.1 50S ribosomal protein L34 -
NLY77_RS10610 (NLY77_10610) 2124789..2125784 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
NLY77_RS10615 (NLY77_10615) 2125804..2126616 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NLY77_RS10620 (NLY77_10620) 2126600..2126959 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T250555 WP_013730620.1 NZ_CP100431:c2121883-2121626 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT250555 WP_002939010.1 NZ_CP100431:c2122145-2121885 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References