Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1959170..1959689 Replicon chromosome
Accession NZ_CP100430
Organism Streptococcus suis strain LSS42

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8LUE3
Locus tag NLY76_RS09465 Protein ID WP_024401197.1
Coordinates 1959170..1959427 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0Z8LUA1
Locus tag NLY76_RS09470 Protein ID WP_044674719.1
Coordinates 1959429..1959689 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY76_RS09450 (NLY76_09450) 1955802..1957532 - 1731 WP_024409898.1 membrane protein -
NLY76_RS09455 (NLY76_09455) 1957733..1958605 - 873 WP_015647465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NLY76_RS09460 (NLY76_09460) 1958626..1959156 - 531 WP_024389507.1 DUF1697 domain-containing protein -
NLY76_RS09465 (NLY76_09465) 1959170..1959427 - 258 WP_024401197.1 Txe/YoeB family addiction module toxin Toxin
NLY76_RS09470 (NLY76_09470) 1959429..1959689 - 261 WP_044674719.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLY76_RS09475 (NLY76_09475) 1959765..1960219 - 455 Protein_1828 8-oxo-dGTP diphosphatase -
NLY76_RS09480 (NLY76_09480) 1960223..1960591 - 369 WP_024401195.1 hypothetical protein -
NLY76_RS09485 (NLY76_09485) 1960584..1961153 - 570 WP_024401194.1 ribonuclease M5 -
NLY76_RS09490 (NLY76_09490) 1961137..1961919 - 783 WP_079397943.1 TatD family hydrolase -
NLY76_RS09495 (NLY76_09495) 1962026..1962163 - 138 WP_002939016.1 50S ribosomal protein L34 -
NLY76_RS09500 (NLY76_09500) 1962331..1963326 - 996 WP_044684315.1 RNA-binding cell elongation regulator Jag/EloR -
NLY76_RS09505 (NLY76_09505) 1963346..1964158 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NLY76_RS09510 (NLY76_09510) 1964142..1964501 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10293.77 Da        Isoelectric Point: 7.3119

>T250551 WP_024401197.1 NZ_CP100430:c1959427-1959170 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQEKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADKLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9906.24 Da        Isoelectric Point: 5.1255

>AT250551 WP_044674719.1 NZ_CP100430:c1959689-1959429 [Streptococcus suis]
MEAIAYSHFRNHLKDYMKKVNDEFEPLIVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8LUE3

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8LUA1

References