250541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2304212..2304729 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NLG45_RS11345 Protein ID WP_000113262.1
Coordinates 2304463..2304729 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NLG45_RS11340 Protein ID WP_000584501.1
Coordinates 2304212..2304463 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS11315 (NLG45_11315) 2300056..2301375 + 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
NLG45_RS11320 (NLG45_11320) 2301454..2302704 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
NLG45_RS11325 (NLG45_11325) 2302959..2303321 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NLG45_RS11330 (NLG45_11330) 2303340..2303939 + 600 WP_000162813.1 DsbA family protein -
NLG45_RS11335 (NLG45_11335) 2303946..2304047 + 102 WP_031774922.1 hypothetical protein -
NLG45_RS11340 (NLG45_11340) 2304212..2304463 + 252 WP_000584501.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLG45_RS11345 (NLG45_11345) 2304463..2304729 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NLG45_RS11350 (NLG45_11350) 2304764..2304841 + 78 Protein_2232 hypothetical protein -
NLG45_RS11355 (NLG45_11355) 2305025..2306575 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NLG45_RS11360 (NLG45_11360) 2306761..2307228 + 468 WP_000153344.1 SRPBCC domain-containing protein -
NLG45_RS11365 (NLG45_11365) 2307315..2307497 + 183 WP_000079142.1 hypothetical protein -
NLG45_RS11370 (NLG45_11370) 2307714..2308538 + 825 WP_000572040.1 formate/nitrite transporter family protein -
NLG45_RS11375 (NLG45_11375) 2308772..2309308 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2300056..2301375 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T250541 WP_000113262.1 NZ_CP100428:2304463-2304729 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9406.58 Da        Isoelectric Point: 4.3407

>AT250541 WP_000584501.1 NZ_CP100428:2304212-2304463 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPSNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure

References