250540

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2277559..2277743 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag NLG45_RS11205 Protein ID WP_000482647.1
Coordinates 2277559..2277666 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2277683..2277743 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS11180 (NLG45_11180) 2272932..2273405 + 474 WP_000456489.1 GyrI-like domain-containing protein -
NLG45_RS11185 (NLG45_11185) 2273528..2274739 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
NLG45_RS11190 (NLG45_11190) 2274921..2275580 - 660 WP_000831298.1 membrane protein -
NLG45_RS11195 (NLG45_11195) 2275640..2276781 - 1142 Protein_2201 glycerate kinase -
NLG45_RS11200 (NLG45_11200) 2277039..2277425 + 387 WP_000779360.1 flippase GtxA -
NLG45_RS11205 (NLG45_11205) 2277559..2277666 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2277683..2277743 - 61 - - Antitoxin
NLG45_RS11210 (NLG45_11210) 2278370..2280133 + 1764 WP_254414320.1 ABC transporter ATP-binding protein -
NLG45_RS11215 (NLG45_11215) 2280158..2281891 + 1734 Protein_2205 ABC transporter ATP-binding protein/permease -
NLG45_RS11220 (NLG45_11220) 2282122..2282289 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T250540 WP_000482647.1 NZ_CP100428:2277559-2277666 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT250540 NZ_CP100428:c2277743-2277683 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References