Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2245759..2246258 Replicon chromosome
Accession NZ_CP100428
Organism Staphylococcus aureus strain RMSA24

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NLG45_RS11065 Protein ID WP_000074044.1
Coordinates 2246016..2246258 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NLG45_RS11060 Protein ID WP_000587618.1
Coordinates 2245759..2246016 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG45_RS11040 (NLG45_11040) 2240826..2242019 + 1194 WP_000675411.1 MFS transporter -
NLG45_RS11045 (NLG45_11045) 2242257..2243006 - 750 WP_000072459.1 CPBP family lipoprotein N-acylation protein LnsB -
NLG45_RS11050 (NLG45_11050) 2243201..2244777 + 1577 Protein_2172 FMN-binding glutamate synthase family protein -
NLG45_RS11055 (NLG45_11055) 2244945..2245400 - 456 WP_000732082.1 DUF1307 domain-containing protein -
NLG45_RS11060 (NLG45_11060) 2245759..2246016 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLG45_RS11065 (NLG45_11065) 2246016..2246258 + 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
NLG45_RS11070 (NLG45_11070) 2246615..2247691 + 1077 WP_001076672.1 M42 family metallopeptidase -
NLG45_RS11075 (NLG45_11075) 2247939..2248601 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NLG45_RS11080 (NLG45_11080) 2248594..2249370 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NLG45_RS11085 (NLG45_11085) 2249766..2250953 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T250539 WP_000074044.1 NZ_CP100428:2246016-2246258 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT250539 WP_000587618.1 NZ_CP100428:2245759-2246016 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References